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CLIP-domain serine proteases in Drosophila innate immunity

Title
CLIP-domain serine proteases in Drosophila innate immunity
Authors
Jang, In-HwanNam, Hyuck-JinLee, Won-Jae
Ewha Authors
이원재
Issue Date
2008
Journal Title
BMB REPORTS
ISSN
1976-6696JCR Link
Citation
vol. 41, no. 2, pp. 102 - 107
Keywords
CLIP domainDrosophilapro-phenoloxidaseserine proteasetoll
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip'qike domain and are therefore referred to as CLIP-domain serine protease (clip-SP), have been found to be involved in unique biological processes, such as immunity and development. Despite the increasing amount of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. Here, the current knowledge regarding Drosophila clip-SPs has been summarized and future research directions to evaluate the role that clip-SPs play in Drosophila immunity are discussed.
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일반대학원 > 바이오융합과학과 > Journal papers
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