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Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria

Title
Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria
Authors
Oh, O-JinMin, Hye-YoungLee, Sang Kook
Ewha Authors
이상국
Issue Date
2007
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link
Citation
vol. 30, no. 10, pp. 1236 - 1239
Keywords
curdioneCurcuma zedoariaprostaglandin E-2cyclooxygenase-2
Publisher
PHARMACEUTICAL SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and cancer chemopreventive agents. In our continuous efforts to search anti-inflammatory and chemopreventive agents from natural products, bioassay-guided fractionation led to the isolation of curdione from the rhizome of Curcuma zedoaria with the inhibitory effect on the production of prostaglandin E-2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells in a concentration-dependent manner (IC50 = 1-1 mu M). Mechanistic studies suggest that the suppression of cyclooxygenase-2 (COX-2) mRNA expression is, at least in part, involved in this inhibitory activity of curdione.
DOI
10.1007/BF02980264
Appears in Collections:
약학대학 > 약학과 > Journal papers
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