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Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria
- Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria
- Oh, O-Jin; Min, Hye-Young; Lee, Sang Kook
- Ewha Authors
- Issue Date
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- vol. 30, no. 10, pp. 1236 - 1239
- curdione; Curcuma zedoaria; prostaglandin E-2; cyclooxygenase-2
- PHARMACEUTICAL SOC KOREA
- SCIE; SCOPUS; KCI
- Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and cancer chemopreventive agents. In our continuous efforts to search anti-inflammatory and chemopreventive agents from natural products, bioassay-guided fractionation led to the isolation of curdione from the rhizome of Curcuma zedoaria with the inhibitory effect on the production of prostaglandin E-2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells in a concentration-dependent manner (IC50 = 1-1 mu M). Mechanistic studies suggest that the suppression of cyclooxygenase-2 (COX-2) mRNA expression is, at least in part, involved in this inhibitory activity of curdione.
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