View : 132 Download: 0

Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria

Title
Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria
Authors
Oh, O-JinMin, Hye-YoungLee, Sang Kook
Ewha Authors
이상국
Issue Date
2007
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link
Citation
ARCHIVES OF PHARMACAL RESEARCH vol. 30, no. 10, pp. 1236 - 1239
Keywords
curdioneCurcuma zedoariaprostaglandin E-2cyclooxygenase-2
Publisher
PHARMACEUTICAL SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and cancer chemopreventive agents. In our continuous efforts to search anti-inflammatory and chemopreventive agents from natural products, bioassay-guided fractionation led to the isolation of curdione from the rhizome of Curcuma zedoaria with the inhibitory effect on the production of prostaglandin E-2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells in a concentration-dependent manner (IC50 = 1-1 mu M). Mechanistic studies suggest that the suppression of cyclooxygenase-2 (COX-2) mRNA expression is, at least in part, involved in this inhibitory activity of curdione.
DOI
10.1007/BF02980264
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE