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Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular diseased

Title
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular diseased
Authors
Johnson, Richard J.Segal, Mark S.Sautin, YuriNakagawa, TakahikoFeig, Daniel I.Kang, Duk-HeeGersch, Michael S.Benner, StevenSanchez-Lozada, Laura G.
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2007
Journal Title
AMERICAN JOURNAL OF CLINICAL NUTRITION
ISSN
0002-9165JCR Link
Citation
vol. 86, no. 4, pp. 899 - 906
Keywords
fructoseuric acidsugararteriosclerosisendotheliall dysfunctionhypertensionobesitychronic kidney diseasemetabolic syndrome
Publisher
AMER SOC CLINICAL NUTRITION
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Currently, we are experiencing an epidemic of cardiorenal disease characterized by increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney disease. Whereas excessive caloric intake and physical inactivity are likely important factors driving the obesity epidemic, it is important to consider additional mechanisms. We revisit an old hypothesis that sugar, particularly excessive fructose intake, has a critical role in the epidemic of cardiorenal disease. We also present evidence that the unique ability of fructose to induce an increase in uric acid may be a major mechanism by which fructose can cause cardiorenal disease. Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis.
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의과대학 > 의학과 > Journal papers
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