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Emerging need for vaccination against hepatitis A virus in patients with chronic liver disease in Korea

Title
Emerging need for vaccination against hepatitis A virus in patients with chronic liver disease in Korea
Authors
Song, Hyun JooKim, Tae HunSong, Ji HyunOh, Hee JungRyu, Kum HeiYeom, Hye JungKim, Seong-EunJung, Hye-KyungShim, Ki-NamJung, Sung-AeYoo, KwonMoon, Il-HwanChung, Kyu Won
Ewha Authors
문일환유권정성애정혜경심기남김태헌정규원김성은
SCOPUS Author ID
문일환scopus; 유권scopus; 정성애scopus; 정혜경scopus; 심기남scopus; 김태헌scopus; 김성은scopus
Issue Date
2007
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link
Citation
vol. 22, no. 2, pp. 218 - 222
Keywords
hepatitis Avaccinationliver diseaseimmunity
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Vaccination against hepatitis A virus (HAV) is recommended for patients with chronic liver disease (CLD), but this has been deemed unnecessary in Korea since the immunity against HAV was almost universal in adults. However, this practice has never been reevaluated with respect to the changing incidence of adult acute hepatitis A. We retrospectively reviewed the medical records of 278 patients with acute hepatitis A diagnosed from January 1995 to November 2005 and prospectively tested 419 consecutive CLD patients from July to December 2005 for the presence of IgG anti-HAV. The number of patients with acute hepatitis A has markedly increased recently, and the proportion of adult patients older than 30 yr has been growing from 15.2% during 1995-1999, to 28.4% during 2000-2005 (p=0.019). Among 419 CLD patients, the seroprevalences of IgG anti-HAV were 23.1% for those between 26 and 30 yr, 64% between 31 and 35 yr, and 85.0% between 36 and 40 yr. These data demonstrate that immunity against HAV is no more universal in adult and substantial proportion of adult CLD patients are now at risk of HAV infection in Korea. Therefore, further study on seeking proper strategy of active immunization against HAV is warranted in these populations.
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의학전문대학원 > 의학과 > Journal papers
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