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Insertion/deletion polymorphism of angiotensin converting enzyme gene in Kawasaki disease

Title
Insertion/deletion polymorphism of angiotensin converting enzyme gene in Kawasaki disease
Authors
Shim, YHKim, HSSohn, SHong, YM
Ewha Authors
홍영미김혜순손세정
SCOPUS Author ID
홍영미scopus; 김혜순scopus; 손세정scopus
Issue Date
2006
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link
Citation
vol. 21, no. 2, pp. 208 - 211
Keywords
mucocutaneous lymph node syndromeKawasaki diseasepeptidyl-dipeptidase Aangiotensin converting enzymepolymorphismgenetic
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Polymorphism of angiotensin converting enzyme (ACE) gene is reported to be associated with ischemic heart disease, hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy. In this study, we investigated the relationship between Kawasaki disease and insertion/deletion polymorphism of ACE gene. Fifty five Kawasaki disease patients and 43 healthy children were enrolled. ACE genotype was evaluated from each of the subjects' DNA fragments through polymerase chain reaction (PCR). Frequencies of ACE genotypes (DID, ID, 11) were 12.7%, 60.0%, 27.3% in Kawasaki group, and 41.9%, 30.2%, 27.9% in control group respectively, indicating low rate of DD and high rate of ID genotype among Kawasaki patients (P < 0.01). Comparing allelic (1, D) frequencies, I allele was more prevalent in Kawasaki group than in control group (57.3% vs. 43.0%, p < 0.05). In Kawasaki group, both genotype and allelic frequencies were not statistically different between those with coronary dilatations and those without. ACE gene I/D polymorphism is thought to be associated with Kawasaki disease but not with the development of coronary dilatations.
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의학전문대학원 > 의학과 > Journal papers
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