Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서주영 | - |
dc.date.accessioned | 2016-08-27T02:08:23Z | - |
dc.date.available | 2016-08-27T02:08:23Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | OAK-3112 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215948 | - |
dc.description.abstract | Although dendritic cells (DCs) located in the small intestinal lamina propria (LP-DCs) migrate to mesenteric lymph nodes (MLNs) constitutively, it is unclear which chemokines regulate their trafficking to NILNs. In this study we report that LP-DCs in unperturbed mice require CCR7 to migrate to MLNs. In vitro, LP-DCs expressing CCR7 migrated toward CCL21, although the LP-DCs appeared morphologically and phenotypically immature. In NILNs, DCs bearing the unique LP-DC phenotype (CD11c(high)CD8 alpha(int)CD11b(low)alpha(L)(low)beta(7) and CD11c(high)CD8 alpha(-)CD11b(high) alpha(L)(low)beta(7)(high)) were abundant in wild-type mice, but were markedly fewer in CCL19-, CCL21-Ser-deficient plt/plt mice and were almost absent in CCR7-deficient mice, indicating the critical importance of CCR7 in LP-DC trafficking to MLNs. Interestingly, CCR7(+) DCs in MLNs with the unique LP-DC phenotype had numerous vacuoles containing cellular debris in the cytoplasm, although MLN-DCs themselves were poorly phagocytic, suggesting that the debris was derived from the LP, where the LP-DCs ingested apoptotic intestinal epithelial cells (IECs). Consistent with this, LP-DCs ingested IECs vigorously in vitro. By presenting IEC-associated Ag, the LP-DCs also induce T cells to produce IL-4 and IL-10. Collectively, these results strongly suggest that LP-DCs with unique immunomodulatory activities migrate to NILNs in a CCR7-dependent manner to engage in the presentation of IEC-associated Ags acquired in the LP. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | CCR7 is critically important in intestinal lamina propria for migration of dendritic cells to mesenteric lymph nodes | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 176 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 803 | - |
dc.relation.lastpage | 810 | - |
dc.relation.journaltitle | JOURNAL OF IMMUNOLOGY | - |
dc.identifier.wosid | WOS:000234553800017 | - |
dc.identifier.scopusid | 2-s2.0-30744474950 | - |
dc.author.google | Jang, MH | - |
dc.author.google | Sougawa, N | - |
dc.author.google | Tanaka, T | - |
dc.author.google | Hirata, T | - |
dc.author.google | Hiroi, T | - |
dc.author.google | Tohya, K | - |
dc.author.google | Guo, ZJ | - |
dc.author.google | Umemoto, E | - |
dc.author.google | Ebisuno, Y | - |
dc.author.google | Yang, BG | - |
dc.author.google | Seoh, JY | - |
dc.author.google | Lipp, M | - |
dc.author.google | Kiyono, H | - |
dc.author.google | Miyasaka, M | - |
dc.contributor.scopusid | 서주영(6603709174;57209001625) | - |
dc.date.modifydate | 20230210140937 | - |