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Reduction in visceral adiposity is highly related to improvement in vascular endothelial dysfunction among obese women: An assessment of endothelial function by radial artery pulse wave analysis

Title
Reduction in visceral adiposity is highly related to improvement in vascular endothelial dysfunction among obese women: An assessment of endothelial function by radial artery pulse wave analysis
Authors
Park, SHShim, KW
Ewha Authors
박시훈심경원
SCOPUS Author ID
박시훈scopus; 심경원scopus
Issue Date
2005
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
0513-5796JCR Link
Citation
vol. 46, no. 4, pp. 511 - 518
Keywords
augmentation indexvisceral adiposityvascular endothelial dysfunction
Publisher
YONSEI UNIV COLLEGE MEDICINE
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Because obesity is frequently complicated by other cardiovascular risk factors, the impact of a reduction in visceral adiposity on vascular endothelial dysfunction (VED) in obese patients is difficult to determine. In the present study, we evaluated the impact of a reduction in visceral adiposity on VED in obese women. Thirty-six premenopausal obese women (BMI >= 25 kg/m(2)) without complications were enrolled in the study. VED was evaluated by determining the augmentation index (AIx) from radial artery pulse waves obtained by applanation tonometry. Changes in AIx in response to nitroglycerin-induced endothelium-independent vasodilatation (Delta AIx-NTG) and in response to salbutamol administration (Delta AIx-Salb) were determined before and after weight reduction. After a 12-week weight reduction program, the average weight loss was 7.96 +/- 3.47 kg, with losses of 21.88 +/- 20.39 cm(2) in visceral fat areas (p < 0.001). Pulse wave analysis combined with provocative pharmacological testing demonstrated preserved endothelium-independent vasodilation in healthy premenopausal obese women (Delta AIx-NTG: 31.36 +/- 9.80% before weight reduction vs. 28.25 +/- 11.21 % after weight reduction, p > 0.1) and an improvement in endothelial-dependent vasodilation following weight reduction (Delta AIx-Salb: 10.03 +/- 6.49% before weight reduction vs. 19.33 +/- 9.28 % after reduction, p < 0.001). A reduction in visceral adipose tissue was found to be most significantly related to an increase in Delta AIx-Salb (beta=-0.57, p < 0.001). A reduction in visceral adiposity was significantly related to an improvement in VED. This finding suggests that reduction of visceral adiposity may be as important as the control of other major risk factors in the prevention of atherosclerosis in obese women.
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의학전문대학원 > 의학과 > Journal papers
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