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Neuroprotective effect of wogonin: Potential roles of inflammatory cytokines

Title
Neuroprotective effect of wogonin: Potential roles of inflammatory cytokines
Authors
Piao, HZJin, SAChun, HSLee, JCKim, WK
Ewha Authors
김원기이재철
Issue Date
2004
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link
Citation
vol. 27, no. 9, pp. 930 - 936
Keywords
wogoninNF-kappa Bmicrogliacytokineneuroprotection
Publisher
PHARMACEUTICAL SOCIETY KOREA
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Wogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflammatory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-alpha and IL-6 in lipopolisaccharicle-stimulated microglial cells. While wogonin reduced the activity of NF-kappaB, it did not change the activity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharicle-stimulated production of NO and cytokines was significantly blocked by various kinds of NF-kappaB inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the over-activation of microglial cells, possibly by inactivating NF-kappaB signaling pathway.
DOI
10.1007/BF02975846
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자연과학대학 > 화학·나노과학전공 > Journal papers
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