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Neuroprotective effect of wogonin: Potential roles of inflammatory cytokines
- Neuroprotective effect of wogonin: Potential roles of inflammatory cytokines
- Piao, HZ; Jin, SA; Chun, HS; Lee, JC; Kim, WK
- Ewha Authors
- 김원기; 이재철
- Issue Date
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- vol. 27, no. 9, pp. 930 - 936
- wogonin; NF-kappa B; microglia; cytokine; neuroprotection
- PHARMACEUTICAL SOCIETY KOREA
- SCIE; SCOPUS; KCI
- Wogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflammatory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-alpha and IL-6 in lipopolisaccharicle-stimulated microglial cells. While wogonin reduced the activity of NF-kappaB, it did not change the activity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharicle-stimulated production of NO and cytokines was significantly blocked by various kinds of NF-kappaB inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the over-activation of microglial cells, possibly by inactivating NF-kappaB signaling pathway.
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