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Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension

Title
Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension
Authors
Feig, DINakagawa, TKarumanchi, SAOliver, WJKang, DHFinch, JJohnson, RJ
Ewha Authors
강덕희
SCOPUS Author ID
강덕희scopus
Issue Date
2004
Journal Title
KIDNEY INTERNATIONAL
ISSN
0085-2538JCR Link
Citation
vol. 66, no. 1, pp. 281 - 287
Keywords
essential hypertensionchildrenendotheliumclinical trial
Publisher
BLACKWELL PUBLISHING INC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Background. Essential hypertension affects more than 25% of the world's population. Genetic, physiologic, and epidemiologic studies provide clues to its origins, but a clear understanding has been elusive. Recent experimental and clinical studies have implicated uric acid in the onset of essential hypertension. Methods. In a retrospective chart review, we identified 95 children with confirmed, new onset hypertension, and evaluated the cause of hypertension and parental history of hypertension, birth weight, and serum uric acid. In an open-label, cross-over trial we treated 5 children with confirmed essential hypertension with allopurinol as single treatment agent, and screened for change in blood pressure by casual and ambulatory methods. In tissue culture experiments, we evaluated the effect of uric acid on glomerular endothelial cell function. Results. Elevation of serum uric acid is related to the onset of essential hypertension in children, reduced birth weight, and endothelial dysfunction. Normalization of uric acid appears to ameliorate new onset essential hypertension. Conclusion. These findings, combined with animal model data, support the hypothesis that uric acid has a key role in the pathogenesis of early onset essential hypertension, and may unify some of the disparate theories of the origins of essential hypertension.
DOI
10.1111/j.1523-1755.2004.00729.x
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의학전문대학원 > 의학과 > Journal papers
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