Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정영해 | - |
dc.date.accessioned | 2016-08-27T02:08:50Z | - |
dc.date.available | 2016-08-27T02:08:50Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.other | OAK-1617 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215600 | - |
dc.description.abstract | The AICD ( amyloid precursor protein [APP] intracellular domain) and C31, the caspase-cleaved C-terminal fragment of APP, have been found in the brains of patients with Alzheimer's disease (AD). Here, we demonstrate for the first time that the C-terminal fragments of APP (AICD [C57, C59] and C31) exert neurotoxicity on differentiated PC 12 cells and rat primary cortical neurons by inducing the expression of glycogen synthase kinase 3beta, forming a ternary complex with Fe65 and CP2/LSF/LBP1 in the nucleus, whereas deletion mutants and a point mutant with Y682G of the YENPTY domain, a Fe65 binding domain, do not. Moreover, expression of APP770 and Swedish mutant form of APP increased the levels of C-terminal fragments of APP (APP-CTs) in neuronal cells and also induced the up-regulation of glycogen synthase kinase-3beta at both the mRNA and the protein levels. In addition, we show that CP2/LSF/LBP1 binding site (nt + 0 to similar to+ 10) in human glycogen synthase kinase 3beta promoter region is essential for the induction of the gene transcription by APP-CTs. The neurotoxicities induced by APP-CTs ( AICD and C31) were accompanied by an increase in the active form of glycogen synthase knase-3beta, and by the induction of tau phosphorylation and a reduction in nuclear beta-catenin levels, and led to apoptosis. | - |
dc.language | English | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.subject | Alzheimer's disease | - |
dc.subject | Fe65 | - |
dc.subject | CP2/LSF/LBP1 transcription factor | - |
dc.subject | AICD | - |
dc.title | C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3 beta expression | - |
dc.type | Article | - |
dc.relation.issue | 11 | - |
dc.relation.volume | 17 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1951 | - |
dc.relation.lastpage | + | - |
dc.relation.journaltitle | FASEB JOURNAL | - |
dc.identifier.doi | 10.1096/fj.03-0106fje | - |
dc.identifier.wosid | WOS:000185345100014 | - |
dc.author.google | Kim, HS | - |
dc.author.google | Kim, EM | - |
dc.author.google | Lee, JP | - |
dc.author.google | Park, CH | - |
dc.author.google | Kim, S | - |
dc.author.google | Seo, JH | - |
dc.author.google | Chang, KA | - |
dc.author.google | Yu, E | - |
dc.author.google | Jeong, SJ | - |
dc.author.google | Chong, YH | - |
dc.author.google | Suh, YH | - |
dc.contributor.scopusid | 정영해(7201371824) | - |
dc.date.modifydate | 20180901081003 | - |