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Differential expression of proteins of caspases and Bcl-2 families in the brain of mice

Title
Differential expression of proteins of caspases and Bcl-2 families in the brain of mice
Authors
Min, SHHwang, DYKang, TSHwang, JHLim, CHLee, SHLim, HJSeo, SJSheen, YYPaik, SGCho, JSKim, YK
Ewha Authors
신윤용
SCOPUS Author ID
신윤용scopus
Issue Date
2003
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN
1107-3756JCR Link
Citation
vol. 12, no. 2, pp. 181 - 183
Keywords
caspaseBcl-2Baxdevelopment
Publisher
PROFESSOR D A SPANDIDOS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Apoptosis is an important process in the variety of different biological system including cell death and embryonic development. Inappropriate apoptosis is implicated in many human diseases such as Alzheimer's disease. Central component of the machinery of apoptosis program in neurons of patients with Alzheimer's disease includes proteins of caspases and Bcl-2 families. We examined whether endogenous protein levels of caspases and Bcl-2 families are expressed in a differential manner during the embryonic and postnatal development of BDF1 strain. Here, all four proteins with caspases-3, -9, Bcl-2 and Bax were highly expressed between embryonic day 19 and 1 week age of early postnatal development, but thereafter the expression dramatically declined. These patterns are needed to compare the proteins in the brains of APPsw-transgenic mice that are expected to be expressed highly in the brain of adult mice. Thus, the results are useful to understand fundamentally the mechanisms of the apoptotic changes during the embryonic and postnatal development of Alzheimer's model mice.
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약학대학 > 약학과 > Journal papers
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