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Localized H-1-MR spectroscopy in moyamoya disease before and after revascularization surgery

Title
Localized H-1-MR spectroscopy in moyamoya disease before and after revascularization surgery
Authors
Lim, SMChoi, HYSuh, JSLee, JHLim, KHSuh, DCLee, HKLim, THRa, YS
Ewha Authors
서정수임수미
SCOPUS Author ID
서정수scopusscopus; 임수미scopus
Issue Date
2003
Journal Title
KOREAN JOURNAL OF RADIOLOGY
ISSN
1229-6929JCR Link
Citation
vol. 4, no. 2, pp. 71 - 78
Publisher
KOREAN RADIOLOGICAL SOC
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Objective: To evaluate, using localized proton magnetic resonance spectroscopy (H-1-MRS), the cerebral metabolic change apparent after revascularization surgery in patients with moyamoya disease. Materials and Methods: Sixteen children with moyamoya disease and eight age-matched normal controls underwent MR imaging, MR angiography, conventional angiography, and Tc-99m- ECD SPECT. Frontal white matter and the basal ganglia of both hemispheres were subjected to localized H-1-MRS, and after revascularization surgery, four patients underwent follow-up H-1-MRS. Results: Decreased NAA/Cr ratios (1.35 +/- 0.14 in patients vs. 1.55 +/- 0.24 in controls) and Cho/Cr ratios (0.96 +/- 0.13 in patients vs. 1.10 +/- 0.11 in controls) were observed in frontal white matter. After revascularization surgery, NAA/Cr and Cho/Cr ratios in this region increased. In the basal ganglia, there is no abnormal metabolic ratios. Conclusion: Localized H-1-MRS revealed abnormal metabolic change in both hemispheres of children with moyamoya disease. Because of its non-invasive nature, H-1-MRS is potentially useful for the preoperative evaluation of metabolic abnormalities and their postoperative monitoring.
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의학전문대학원 > 의학과 > Journal papers
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