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Long-lasting facilitation by dehydroevodiamine center dot HCl of synaptic responses evoked in the CA1 region of rat hippocampal slices

Title
Long-lasting facilitation by dehydroevodiamine center dot HCl of synaptic responses evoked in the CA1 region of rat hippocampal slices
Authors
Park, EJSuh, YHKim, JYChoi, SLee, CJ
Ewha Authors
최석우
Issue Date
2003
Journal Title
NEUROREPORT
ISSN
0959-4965JCR Link
Citation
vol. 14, no. 3, pp. 399 - 403
Keywords
acetykcholinesterase inhibitordehydroevodiamine center dot HClhippocampuslong-lasting facilitation
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We tested the effects of dehydroevodiamine . Cl (DHED) on field excitatory postsynaptic potentials (fEPSPs) evoked by the electrical stimulation of Schaffer collaterals-commissural fibres in the CAI region of rat hippocampal slices. Bath applications of 10 muM DHED for 20 or 40 min induced long-lasting facilitation of fEPSPs, which outlasted the presence of DHED. A 10 min treatment with a higher concentration (100 muM) also induced long-lasting facilitation. The long-lasting facilitation was blocked either by 10 muM atropine, the muscarinic receptor antagonist, or by 50 muM D-2-amino-5-phosphonopentanoic acid (D-AP5), an NMDA receptor antagonist. These results show that DHED produces long-lasting facilitation of synaptic transmission, and that this facilitation depends upon the activation of both the muscarinic and NMDA receptors.
DOI
10.1097/01.wnr.0000058035.29600.24
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의학전문대학원 > 의학과 > Journal papers
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