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Orientia tsutsugamushi inhibits apoptosis of macrophages by retarding intracellular calcium release

Title
Orientia tsutsugamushi inhibits apoptosis of macrophages by retarding intracellular calcium release
Authors
Kim, MKSeong, SYSeoh, JYHan, THSong, HJLee, JEShin, JHLim, BUKang, JS
Ewha Authors
서주영
SCOPUS Author ID
서주영scopus
Issue Date
2002
Journal Title
INFECTION AND IMMUNITY
ISSN
0019-9567JCR Link
Citation
vol. 70, no. 8, pp. 4692 - 4696
Publisher
AMER SOC MICROBIOLOGY
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Orientia tsutsugamushi shows both pro- and antiapoptotic activities in infected vertebrate cells. Apoptosis of THP-1 cells induced by beauvericin was inhibited by O. tsutsugamushi infection. Beauvericin-induced calcium redistribution was significantly reduced and retarded in cells infected with O. tsutsugamushi. Antiapoptotic activities of O. tsutsugamushi in infected cells are most probably due to inhibition of the increase in the cytosolic calcium concentration.
DOI
10.1128/IAI.70.8.4692-4696.2002
Appears in Collections:
의과대학 > 의학과 > Journal papers
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