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Upregulation of MUC8 and downregulation of MUC5AC by inflammatory mediators in human nasal polyps and cultured nasal epithelium

Title
Upregulation of MUC8 and downregulation of MUC5AC by inflammatory mediators in human nasal polyps and cultured nasal epithelium
Authors
Seong, JKKoo, JSLee, WJKim, HNPark, JYSong, KSHong, JHYoon, JH
Ewha Authors
이원재
Issue Date
2002
Journal Title
ACTA OTO-LARYNGOLOGICA
ISSN
0001-6489JCR Link
Citation
vol. 122, no. 4, pp. 401 - 407
Keywords
MUC8MUC5ACmucinsnasal polyps
Publisher
TAYLOR & FRANCIS AS
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Polyps are believed to be the source of mucus hypersecretion in chronic inflammation of the sinus. However, it is not clear which mucins are responsible for the hypersecretion of mucus by nasal polyps. We describe the over-expression of MUC8 mRNA in nasal polyps and the upregulation of MUC8 mRNA expression and downregulation of MUC5AC mRNA expression by inflammatory mediators. We found that the level of MUC8 mRNA, but not the level of MUC5AC mRNA, increased in nasal polyps. We also found that there was an increase in intracellular mucin in nasal polyps, compared to the normal nasal inferior turbinate. A mixture of inflammatory mediators increased MUC8 mRNA expression and decreased MUC5AC mRNA expression in cultured normal human nasal epithelial cells. Among inflammatory mediators, IL-4 is responsible for the decrease in MUC5AC mRNA and MUC5AC mucin secretion. These results indicate that MUC8 may be one of the major mucins secreted from the polyp epithelium and that it may play an important role in the pathogenesis of mucus hypersecretion in chronic sinusitis with polyps.
DOI
10.1080/00016480260000094
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일반대학원 > 바이오융합과학과 > Journal papers
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