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Enhanced expression of neuronal nitric oxide synthase and phospholipase C-gamma 1 in regenerating murine neuronal cells by pulsed electromagnetic field

Title
Enhanced expression of neuronal nitric oxide synthase and phospholipase C-gamma 1 in regenerating murine neuronal cells by pulsed electromagnetic field
Authors
Kim, SSShin, HJEom, DWHuh, JRWoo, YKim, HRyu, SHSuh, PGKim, MJKim, JYKoo, TWCho, YHChung, SM
Ewha Authors
정성민
SCOPUS Author ID
정성민scopus
Issue Date
2002
Journal Title
EXPERIMENTAL AND MOLECULAR MEDICINE
ISSN
1226-3613JCR Link
Citation
vol. 34, no. 1, pp. 53 - 59
Keywords
PEMFPLC-gamma 1NOSS-100
Publisher
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Pulsed electromagnetic field (PEMF) has been shown to improve the rate of peripheral nerve regeneration. In the present study we investigated the expression of neuronal nitric oxide synthase (nNOS) and phospholipase C-gamma1 (PLC-gamma1) in regenerating rat laryngeal nerves during the exposure to PEMF after surgical transection and reanastomosis. Axons were found to regenerate into the distal stump nearly twice faster in PEMF-exposed animals than in the control. Consistently, motor function was better recovered in PEMF-treated rats. The expression of nNOS and PLC-gamma1 was highly enhanced in the regenerated nerves.
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의학전문대학원 > 의학과 > Journal papers
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