Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김옥경 | - |
dc.date.accessioned | 2016-08-27T02:08:35Z | - |
dc.date.available | 2016-08-27T02:08:35Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.other | OAK-801 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215441 | - |
dc.description.abstract | The aim of this study was to determine the relationship of a-smooth muscle actin (ASMA) and the proliferation marker Ki-67 of glomerulonephritis (GN). Immunohistochemical stainings with the usual streptavidin-biotin peroxidase method were performed on 86 renal biopsies using monoclonal 1A4 and Ki-67. The results of the quantitative evaluation of ASMA and Ki-67 were analyzed for the correlation between positive value of ASMA and Ki-67 in different GN. ASMA expressions of glomeruli were highest in acute post-infectious GN [APGN; 16.9 Fraction Volume (FV)%], followed by unclassified proliferative GN (UnGN; 12.5 FV%), membranoproliferative GN (MPGN; 8.5 FV%), lupus nephritis (LupusN; 6.3 FV%), IgA nephritis (IgAN; 5.6 FV%), and normal control (0.1 FV%). The Ki-67 staining was considerably elevated in lupusN (4.3 Ki-67 positives/glomerulus), APGN (2.7), MPGN (2.5), UnGN (1.66), IgAN (0.5), compared with that in normal control group (0.1 Ki-67 positives/glomerulus). Ki-67 value in each category of glomerular diseases was significantly different from that in the control biopsies (p < 0.004). The relationship between morphometric results of ASMA and Ki-67 was statistically significant regardless of the diagnosis. (rs = 0.425, p = 0.000, ASMA = 0.1113 + 0.1665 Ki-67). In conclusion, the immunohistochemical assessment of ASMA and Ki-67 expression in GN might be a reliable indicator for the progression of GN. This study indicates that active cellular proliferation is associated with increased actin deposition in glomeruli. | - |
dc.language | English | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | actins | - |
dc.subject | Ki-67 antigen | - |
dc.subject | glomerulonephritis | - |
dc.subject | immunohistochemistry | - |
dc.title | Immunohistochemical study of the expression of alpha-smooth muscle actin and the proliferation marker Ki-67 of glomerulonephritis | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 16 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 455 | - |
dc.relation.lastpage | 461 | - |
dc.relation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.identifier.wosid | WOS:000170672400012 | - |
dc.identifier.scopusid | 2-s2.0-0035434651 | - |
dc.author.google | Kim, O | - |
dc.contributor.scopusid | 김옥경(13409294300;8668949200) | - |
dc.date.modifydate | 20180403152530 | - |