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Inhibitory effect of fangchinoline on excitatory amino acids-induced neurotoxicity in cultured rat cerebellar granule cells

Title
Inhibitory effect of fangchinoline on excitatory amino acids-induced neurotoxicity in cultured rat cerebellar granule cells
Authors
Kim, SDOh, SKKim, HSSeong, YH
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2001
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
ISSN
0253-6269JCR Link
Citation
vol. 24, no. 2, pp. 164 - +
Keywords
fangchinolineexcitatory amino acidsneurotoxicitycerebellar granule cells
Publisher
PHARMACEUTICAL SOCIETY KOREA
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Glutamate receptors-mediated excitotoxicity is believed to play a role in the pathophysiology of neurodegenerative diseases. The present study was performed to evaluate the inhibitory effect of fangchinoline, a bis-benzylisoquinoline alkaloid, which has a characteristic as a Ca2+ channel blocker, on excitatory amino acids (EAAs)-induced neurotoxicity in cultured rat cerebellar granule neuron. Fangchinoline (1 and 5 muM) inhibited glutamate (1 mM), N-methyl-D-aspartate (NMDA; 1 mM) and kainate (100 muM]-induced neuronal cell death which was measured by trypan blue exclusion test. Fangchinoline (1 and 5 muM) inhibited glutamate release into medium induced by NMDA (1 mM) and kainate (100 muM), which was measured by HPLC. And fangchinoline (5 muM) inhibited glutamate [1 mM)-induced elevation of intracellular calcium concentration. These results suggest that inhibition of Ca2+ influx by fangchinoline may contribute to the beneficial effects on neurodegenerative effect of glutamate in pathophysiological conditions.
DOI
10.1007/BF02976485
Appears in Collections:
의과대학 > 의학과 > Journal papers
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