Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한재진 | - |
dc.date.accessioned | 2016-08-27T02:08:30Z | - |
dc.date.available | 2016-08-27T02:08:30Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0003-4975 | - |
dc.identifier.other | OAK-554 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215384 | - |
dc.description.abstract | Background. Reperfusion injury involves leukocyte-endothelial interaction mediated by cell adhesion molecules. This study was designed to determine the time course of intercellular adhesion molecule-1 (ICAM-1) expression and the functional recovery of myocardium when reperfused with leukocyte depleted whole blood. Methods. Sixteen neonatal piglet hearts were harvested and stored with 4 degreesC cold University of Wisconsin Solution (UWS) for 12 hours. An ex vivo model consisting of an isolated working heart perfusion circuit, roller pumps, and a membrane oxygenator, was used for reperfusion. Atrial tissues were taken for staining ICAM-1. The stroke work index (SWI) was calculated during 4 hours of reperfusion. Two groups (group 1: reperfused with whole blood, group 2: with leukocyte depleted blood) were compared. Results. The differences of ICAM-1 expression between group 1 and 2 were significant at 3 and 4 hours of reperfusion (p < 0.05). The differences of the mean stroke work indices were significant at 2, 3, and 4 hours after reperfusion (p < 0.05). Conclusions. Leukocyte-depleted reperfusion attenuates the expression of ICAM-1 and reduces the time-dependent functional deterioration of the myocardium. These results suggest that adhesion molecule like ICAM-1 plays a major role in deteriorating myocardial function during the reperfusion, possibly by leukocyte-mediated inflammatory process. (Ann Thorac Surg 2000;70:1531-5) (C) 2000 by The Society of Thoracic Surgeons. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Correlation between ICAM-1 and functional recovery of piglet myocardium with leukocyte-depleted reperfusion | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 70 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1531 | - |
dc.relation.lastpage | 1535 | - |
dc.relation.journaltitle | ANNALS OF THORACIC SURGERY | - |
dc.identifier.doi | 10.1016/S0003-4975(00)01938-X | - |
dc.identifier.wosid | WOS:000165235400022 | - |
dc.author.google | Lee, JR | - |
dc.author.google | Han, JJ | - |
dc.author.google | Seo, JW | - |
dc.contributor.scopusid | 한재진(7406442540;57193799455) | - |
dc.date.modifydate | 20230301081001 | - |