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Effects of allyl sulfur compounds and garlic extract on the expressions of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines

Title
Effects of allyl sulfur compounds and garlic extract on the expressions of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
Authors
Hong, YSHam, YAChoi, JHKim, J
Ewha Authors
홍영숙
SCOPUS Author ID
홍영숙scopusscopus
Issue Date
2000
Journal Title
EXPERIMENTAL AND MOLECULAR MEDICINE
ISSN
1226-3613JCR Link
Citation
vol. 32, no. 3, pp. 127 - 134
Keywords
DASDADSgarlic extractapoptosisNSCLC
Publisher
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Allyl sulfur compounds play a major role in the chemoprevention against carcinogenesis. The present study compared the antiproliferative effects of diallyl sulfide (DAS), diallyl disulfide (DADS) and garlic extract on p53-wild type H460 and p53-null type H1299 non small cell lung cancer cells (NSCLC). The DAS and DADS treatment of both H460 and H1299 cells resulted in the highest numbers of cells in apoptotic state as measured by acridine orange staining, however, garlic extract treatment did not induce any significant apoptotic cells by MTT assay. DADS was found to be more effective in inducing apoptosis on NSCLC. The level of p53 protein in H460 cell was increased following DADS treatment. DAS and garlic extract treatment of H460 cells induced a rise in the level of Bax and a fall of Bcl-2 level. These results demonstrate that DAS, DADS and garlic extract are effective in reduction of anti-proliperative gene in NSCLC and suggest that modulation of apoptosis-associated cellular proteins by DAS. DADS and garlic extract may be the mechanism for apoptosis which merit further investigation as potential chemoprevention agents.
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의학전문대학원 > 의학과 > Journal papers
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