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Inhibition of progesterone-induced Xenopus oocyte maturation by Nm23

Title
Inhibition of progesterone-induced Xenopus oocyte maturation by Nm23
Authors
Kim, SYFerrell, JEChae, SKLee, KJ
Ewha Authors
이공주
SCOPUS Author ID
이공주scopus
Issue Date
2000
Journal Title
CELL GROWTH & DIFFERENTIATION
ISSN
1044-9523JCR Link
Citation
vol. 11, no. 9, pp. 485 - 490
Publisher
AMER ASSOC CANCER RESEARCH
Indexed
SCOPUS WOS scopus
Abstract
The Nm23 protein has been implicated in a wide variety of biological processes, including suppression of metastasis, phytochrome responses in plants, and regulation of differentiation. Here we examine whether Nm23 is involved in Xenopus laevis oocyte maturation. We found that Nm23 is present in oocytes, indicating that it has the potential to be a regulator of maturation. Furthermore, modest overexpression of Nm23 inhibited progesterone-induced oocyte maturation. This maturation-inhibitory activity was shared by both the acidic Nm23-H1 isoform and the basic Nm23-H2 isoform and by Nm23 mutants that lack nucleoside diphosphate kinase activity (Nm23-H1 H118F and Nm23-H2 H118F), Expression of Nm23 proteins delayed the accumulation of Mos and the activation of p42 mitogen-activated protein kinase (MAPK) in progesterone-treated oocytes but had no discernible effect on Mos-induced p42 MAPK activation. Therefore, Nm23 appears to act upstream of the Mos/mitogen-activated protein/extracellular signal-regulated kinase kinase/p42 MAPK cascade. These findings suggest a novel biological role for Nm23.
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약학대학 > 약학과 > Journal papers
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