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Multicenter study of the treatment of erectile dysfunction with transurethral alprostadil (MUSE) in Korea

Title
Multicenter study of the treatment of erectile dysfunction with transurethral alprostadil (MUSE) in Korea
Authors
Kim, SCAhn, TYChoi, HKChoi, NGChung, TGChung, WSHwang, TKHyun, JSJung, GWKim, CIKim, JJKim, SWLee, CHLee, KSLee, WHMin, KSMoon, KHPaick, JSPark, KSPark, NCPark, YKSeo, JKSeo, KKShin, JSYoon, YRLee, WC
Ewha Authors
정우식
SCOPUS Author ID
정우식scopus
Issue Date
2000
Journal Title
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
ISSN
0955-9930JCR Link
Citation
vol. 12, no. 2, pp. 97 - 101
Keywords
transurethral alprostadilerectile dysfunctionefficacysafety
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
A Korean multicenter study was conducted to assess the effectiveness of transurethral alprostadil with MUSE in 334 subjects with chronic erectile dysfunction (ED) who were enrolled in 21 clinical centers. Patients with psychogenic impotence comprised about 30% of subjects. Intraurethral alprostadil was titrated in a stepwise fashion in the clinics from 250 to 500 or 1000 meg based on erectile response and tolerability. The erectile responses were evaluated using an erection assessment scale (score of 1-5). The dose that produced a maximal penile response of score 5 (full rigid erection) or 4 (full tumescence, partial rigidity) was selected for home treatment. Patients who showed partial erection (score of 3) with 1000 meg were also included in the home-treatment group. In-clinic phase: 198 men (59.3%) had maximal penile responses of score 4 or 5. The rate of maximal responses was not related to patient age, etiology or duration of the ED. A total of 228 (68.3%) men progressed to home treatment. The overall level of comfort of the transurethral alprostadil was rated as uncomfortable or very uncomfortable in 12%. Home phase: During the two-month period of home treatment, 178 (78.1%) men had successful sexual intercourse at least once, and 78.2% of administrations (1976) resulted in successful intercourse. The main causes of drop-out were insufficient erectile response in 27 men (11.8%), adverse reactions (mostly penile or urethral pain) in 7 (3.1%) or both in 7 (3.1%). In conclusion, transurethral alprostadil could be a suitable treatment option for patients with ED regardless of age and etiology of ED. Efficacy in an Asian population (Korea) is comparable to that reported previously in Caucasians.
DOI
10.1038/sj.ijir.3900490
Appears in Collections:
의과대학 > 의학과 > Journal papers
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