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Alterations in extracellular matrix components in transplant glomerulopathy

Title
Alterations in extracellular matrix components in transplant glomerulopathy
Authors
Jeong, HJSung, SHHong, SWMoon, JIKim, SIKim, YSPark, K
Ewha Authors
성순희
SCOPUS Author ID
성순희scopus
Issue Date
2000
Journal Title
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
ISSN
0945-6317JCR Link
Citation
vol. 437, no. 1, pp. 69 - 73
Keywords
transplant glomerulopathyextracellular matrixactininflammatory cells
Publisher
SPRINGER VERLAG
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
The distribution pattern of extracellular matrix (ECM) components in transplant glomerulopathy was studied in relation to light microscopic features, actin expression of mesangial cells, and intraglomerular inflammatory cells. Nine cases of mild (group I) and nine cases of severe (group II) transplant glomerulopathy were stained with antisera against fibronectin (FN), tenascin (TN), collagen types III and IV, smooth muscle actin, CD45RO, CD68, and Ki-67 antigen. The composition of ECM was similar in the two groups. The expanded mesangium was diffusely stained by type-IV collagen, FN and TN, and focally and weakly stained by type-III collagen and smooth muscle actin. Type-IV collagen was linearly stained along the capillary walls, imparting a double-contour feature, whereas FN and TN showed granular staining along the capillary walls. CD68 positive cells were increased in severe transplant glomerulopathy, but this increase was not related to ECM deposition. These findings suggest that increased glomerular deposition of normal and abnormal ECM components participate in the evolution of transplant glomerulopathy.
DOI
10.1007/s004280000193
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의학전문대학원 > 의학과 > Journal papers
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