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Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities

Title
Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities
Authors
Jew, SKim, EJe, SZhao, LXKim, HPark, WKo, KKim, WKim, HJCheong, JHLee, ES
Ewha Authors
김화정
SCOPUS Author ID
김화정scopus
Issue Date
2000
Journal Title
HETEROCYCLES
ISSN
0385-5414JCR Link
Citation
vol. 52, no. 3, pp. 1087 - +
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir ((3)).
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약학대학 > 약학과 > Journal papers
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