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Platelet derived growth factor releasing chitosan sponge for periodontal bone regeneration

Title
Platelet derived growth factor releasing chitosan sponge for periodontal bone regeneration
Authors
Park, YJLee, YMPark, SNSheen, SYChung, CPLee, SJ
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2000
Journal Title
BIOMATERIALS
ISSN
0142-9612JCR Link
Citation
vol. 21, no. 2, pp. 153 - 159
Keywords
chitosan spongeperiodontal bone regenerationplatelet-derived growth factor-BEcontrolled release
Publisher
ELSEVIER SCI LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
With an aim of improving bone regeneration, chitosan sponge containing platelet-derived growth factor-BE (PDGF-BB) were developed. For fabrication of chitosan sponge, chitosan solution was freeze-dried, crosslinked and freeze-dried again. PDGF-BB was incorporated into the chitosan sponge by soaking chitosan sponge into the PDGF-BE solution. Release kinetics of PDGF-BB, cell attachment, proliferation capacity and bony regenerative potentials of PDGF-BB-loaded chitosan sponge were investigated. Prepared chitosan sponge retained porous structure with 100 mu m pore diameter that was suitable for cellular migration and growth. Release rate of PDGF-BB could be controlled by varying initial loading content of PDGF-EB to obtain optimal therapeutic efficacy. PDGF-BB-loaded chitosan sponge induced significantly high cell attachment and proliferation level, which indicated good cellular adaptability. PDGF-BB-loaded chitosan sponge demonstrated marked increase in new bone formation and rapid calcification. Degradation of the chitosan sponge was proceeded at defect site and subsequently replaced with new bone. Histomorphometric analysis confirmed that PDGF-BB-loaded chitosan sponge significantly induced new bone formation. These results suggested that chitosan sponge and PDGF-BB-loaded chitosan sponge may be beneficial to enhance periodontal bone regeneration. (C) 1999 Elsevier Science Ltd. All rights reserved.
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약학대학 > 약학과 > Journal papers
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