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Human antibody responses to capsular polysaccharides of Streptococcus pneumoniae 6B, 14, and 19F

Title
Human antibody responses to capsular polysaccharides of Streptococcus pneumoniae 6B, 14, and 19F
Authors
Kim, JHim, KHKim, JSSong, JHPark, MK
Ewha Authors
김경효
SCOPUS Author ID
김경효scopus
Issue Date
1998
Journal Title
JOURNAL OF MICROBIOLOGY
ISSN
1225-8873JCR Link
Citation
vol. 36, no. 4, pp. 303 - 307
Keywords
antibodyisotypeStreptococcus pneumoniae
Publisher
MICROBIOLOGY SOC KOREA
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Human antibody responses to Streptococcus pneumoniae 6B, 14, and 19F capsular polysaccharide were analyzed. Thirty-one healthy young adults were immunized with the pneumococcal 23-valent PS vaccine. Serum samples were obtained from them before and 1 month after vaccination. The amounts of total antibody, heavy chain and light chain isotypes were determined by enzyme-linked immunosorbent assay (ELISA). Vaccination increased the total levels of anti-6B, anti-14, and anti-19F PS antibodies by 3.4-fold, 3.8-fold and 4.1-fold, respectively. Some individuals showed great variations in antibody responses to different serotypes of PS, The IgG antibody was predominant in the responses to the three PSs, and most of the IgG anti-PS antibodies were IgG2 isotype, There was no significant difference in the kappa and lambda responses.
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의과대학 > 의학과 > Journal papers
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