The authors present a case of spontaneous regression of a herniated cervical nucleus pulposus in a patient with myelopathy. This 37-year-old woman developed sudden quadriparesis; she had reported no history of trauma. Magnetic resonance (MR) imaging revealed a large disc herniation and increased signal intensity of the cord at the C5-6 level. The extruded disc fragment was found to have resolved on follow-up MR imaging after 28 months, despite the fact that the patient had undergone no specific treatment. The patient's symptoms had subsided almost totally. This is the first case of MR-documented regression of a cervical disc herniation in a patient with myelopathy.