Full metadata record
DC Field | Value | Language |
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dc.contributor.advisor | 서명은 | - |
dc.contributor.author | 이지영 | - |
dc.creator | 이지영 | - |
dc.date.accessioned | 2016-08-26T04:08:58Z | - |
dc.date.available | 2016-08-26T04:08:58Z | - |
dc.date.issued | 1990 | - |
dc.identifier.other | OAK-000000016288 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/207590 | - |
dc.identifier.uri | http://dcollection.ewha.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000016288 | - |
dc.description.abstract | 2-Chloro-3-(α-acetyl-α-ethoxycarbcnyl- methyl)-1, 4-naphthoquinone과 2-chloro-3-N-phonylamino-1, 4-naphtho-quinone을 출발물질로 하여 <benzo-[f]-indole> -4, 9- dione 유도체를 합성하였다. 즉 2-Chlore-3-(α-acetyl-α-ethoxycarbonyl-methyl)-1, 4-naphthoquinone과 alkylamine 또는 arylamine류를 반응시켜 2-amino-3-(α-acetyl-α-ethoxycarbonyl- methyl)-1, 4-naphthoquinone 유도체를 만들고 여기에 염기로저 sodium ethoxide를 가해 새로운 <benzo-[f]-indole>-4, 9-dione 유도체를 합성하였다. 2-Chloro-3-N-phenylamino-1, 4- naphtho-quinone과 sodium α-cyano ethyl acetate와 반응시켜 2-amino-3-ethoxycarbonyl-N-phenyl-<benzo-[f]-indole>-4, 9-dione을 얻었다. 그러나 sodium methoxide 존재하에서 diethyl malonate를 반응시켰을 때 <benzo-[f]-indole>-4, 9-dione이 생성되지 않고 2-Chlore-3-bis-(methoxycarbonyl)-methyl-2H-3-N-phonylamino-1, 4-naphthoquinone이 생성되었다.;<Benzo-[f]-indole>-4,9-dione derivatives were prepared from 2-chloro-3-(α-acetyl-α-ethoxycarbonyl-methyl)-1,4-naphthoquinone and 2-chloro-3-N-phenylamino-1,4-naphthoquinone. 2-Chloro-3-(α-acetyl-α-ethoxycarbonyl-methyl)-1,4-naphthoquinone was reacted with amines to give 2-amino-3-(α-acetyl-α-ethoxycarbonyl-methyl)-1,4-naphthoquinone derivatives. Subsequent treatment of 2-amino-3-(α-acetyl-α-ethoxycarbonyl-methyl) -1,4-naphthoquinone with sodium ethoxide gave <benzo-[f]-indole>-4,9-dione derivatives. When 2-chloro-3-N-phenylamino-1,4-naphthoquinone reacted with sodium α-cyano ethyl acetate, 2-amino-3-ethoxycarbonyl-N-phenyl-<benzo-[f]-indole>-4,9-dione was obtained. However, with sodium diethyl malonate not <benzo-[f]-indole>-4,9-dione but 2-chloro-3-bis-(methoxycarbonyl)-methyl-2H-3-N-phenylamino-1,4-naphthoquinone was obtained. | - |
dc.description.tableofcontents | 목차 = ⅲ 논문개요 = ⅴ Ⅰ. 서론 = 1 Ⅱ. 실험재료 및 방법 = 8 A. 시약 및 기기 = 8 B. 실험 = 8 1. 2-Amino-3-(α-acetyl-α-ethoxycarbonyl-methyl)-1,4-naphthoquinone derivatives 의 합성 = 8 2. <Benzo-[f]-indole>-4,9-dione derivatives의 합성 = 12 3. 2-Chloro-3-N-phenylamino-1,4-naphthoquinone과 active methylene compounds와의 반응 = 16 Ⅲ. 결과 및 고찰 = 19 A. 2-Chloro-3-(α-acetyl-α-ethoxycarbonyl-methyl)-1,4-naphthoquinone 과 amine류와의 반응 = 19 B. Ester와 amine과의 분자내 고리화 반응 = 22 C. 2-Chloro-3-N-phenylamino-1,4-naphthoquinone과 active methylene compounds와의 반응 = 25 Ⅳ. 결론 = 29 참고문헌 = 30 부록 = 33 Abstract = 45 | - |
dc.format | application/pdf | - |
dc.format.extent | 1440779 bytes | - |
dc.language | kor | - |
dc.publisher | 이화여자대학교 대학원 | - |
dc.subject | 벤조 | - |
dc.subject | 인돌 | - |
dc.subject | 디온 | - |
dc.subject | 유도체 | - |
dc.title | 벤조-〔f〕-인돌-4, 9-디온 유도체의 합성 | - |
dc.type | Master's Thesis | - |
dc.title.translated | Synthesis of <benzo-〔f〕-indole>-4,9-dione derivatives | - |
dc.creator.othername | Lee, Ji Young | - |
dc.format.page | v, 46 p. | - |
dc.identifier.thesisdegree | Master | - |
dc.identifier.major | 대학원 약학과 | - |
dc.date.awarded | 1990. 2 | - |