The effect of Ca-P coated bovine bone mineral on bone regeneration around dental implant in dogs.

Abstract

Objectives: Recently the immediate implant placement is a widely accepted surgical procedure. The aim of this study is to evaluate the effect of Ca-P coated bovine bone mineral on bone growth around dental implant. Materials and Methods: Two mongrel dogs were used for this study. After 6 weeks after extraction, the surgical procedure including defect preparation and implant installation was performed. The circumferential peri-implant defect of 5mm depth & 7.5mm diameter was made using a trephine bur. After that, 3.5mm diameter and 15mm length of fixture was installed in the center of the defect. As a result, 2.0mm circumferential gap was made between implant fixture and the surrounding bone. The autogenous particulate bone or Biocera?? were filled into the prepared defect. One animal was sacrificed 4 weeks later and the specimens were harvested to investigate. The other animal was sacrificed 8 weeks later and the specimens were harvested to investigate. Block biopsy was performed to evaluate histologic features. Results: Both group exhibited complete bone-fill clinically. On the autogenous bone graft (control) sites the average of bone-to-implant contact (BIC) was 28.2±19% at 4 week, the average of BIC was 44.9±9% at 8 week respectively. On the Biocera?? (test) sites the average of BIC was 34.6±27% at 4 week, the average of BIC was 27.6±23% at 8 week respectively. On the autogenous bone graft (control) sites the average of bone density was 39.7±21% at 4 week, the average of bone density was 41.7±11% at 8 week respectively. On the Biocera?? (test) sites the average of bone density was 32.7±25% at 4 week, the average of bone density was 37.4±17% at 8 week respectively. The mean percentage of the bone-to-implant contact and bone density were similar. Histologically, both autograft site and xenograft site were harmonized well with bone and showed similar healing appearance. There was no significant difference between autograft site and xenograft site(P>0.05). Conclusion: In case that there existed bone defect of 2mm in peri-implant, we concluded that it was filled with new bone in autograft and xenograft and the result was similar for both cases. The results suggest that Biocera?? can be used as a predictable bone substitute for autogenous bone to augment bony defect around implant fixture.