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Identification of Two Flavonoids from Scutellaria baicalensis

Title
Identification of Two Flavonoids from Scutellaria baicalensis
Authors
손영민
Issue Date
2011
Department/Major
대학원 생명·약학부약학전공
Publisher
이화여자대학교 대학원
Degree
Master
Advisors
서은경
Abstract
The roots of Scutellaria baicalensis Georgi (Labiatae), commonly known as skullcap, is perennial plant grown in Korea, China, Mongolia, and Eastern Siberia. All parts of S.baicalensis have been used for an oriental medicine for treating allergy, inflammation, anxiety and convulsion. As part of our ongoing search for bioactive compounds from traditional herbal medicines, the roots of S. baicalen sis was investigated, and affording two known compounds, 2-carboxymethyl-3,5-dihydroxybiphenyl (1) and (2S)-7,2′-dihydroxy-5-methoxy flavanone (2). These two compounds 1 and 2 were isolated from S.baicalensis for the first time in the present study. The structures were identified by spectroscopic data analysis, including 1D and 2D NMR experiments as well as by comparisons of those data with the literature values.;황금 (Scutellaria baicalensis Georgi)은 꿀풀과(Labiatae)에 속하는 식물로 한국, 중국, 일본 등에 분포한다. 속썩은 풀의 주피를 벗긴 뿌리로 Skullcap 이라고도 불린다. Scutellaria 의 여러 종으로부터 flavonoids 및 diterpenoids 등이 분리 보고된바 있다. 본 연구에서는 S.baical ensis 의 EtOAc 추출물로부터 총 12개의 물질을 분리해 내었고, 이 중 2-carboxymethyl-3,5-dihydroxybiphenyl (EA289E-27-56-K1,1),그리고 (2S)-7,2'-dihydroxy-5-methoxyflavanone (EA289E-27-65-K5,2) 물질이 이 식물로부터 처음 분리되었다. 화합물의 구조결정을 위해서 spectroscopic data (1H-, 13C-, HSQC, HMBC, COSY and NOESY NMR)와 문헌조사를 통해 분리된 물질의 구조를 분석하였다.
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