Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 유재상 | - |
dc.contributor.author | Li, Fei | - |
dc.creator | Li, Fei | - |
dc.date.accessioned | 2016-08-26T11:08:57Z | - |
dc.date.available | 2016-08-26T11:08:57Z | - |
dc.date.issued | 2010 | - |
dc.identifier.other | OAK-000000060557 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/203871 | - |
dc.identifier.uri | http://dcollection.ewha.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000060557 | - |
dc.description.abstract | Transforming growth factor-β (TGF-β) 신호 전달은 주로 ALK5/smad2/3 pathway를 통하여 이루어지고 있다. TGF-β 신호 전달의 저해는 피부 상처의 재구성을 촉진시키고 흉터의 섬유화를 억제할 것으로 예상된다. TGF-β 신호 전달의 효과적인 저해 전략을 세우기 위해서는 복잡한 TGF-β 신호 전달의 확실한 이론 정립이 필요하다. 본 연구에서는 triazole 유도체들의 합성하였고, p3TP-Lux assay를 통하여 ALK5 inhibition activity를 확인하였다. 합성한 화합물 가운데 화합물 2 (p3TP-Lux, 21%), 화합물 12a (p3TP-Lux, 6%)의 ALK5 inhibition activity를 측정하였고, 이 두 화합물이 ALK5 저해에 효과가 있음을 확인할 수 있었다.;The transforming growth factor-β (TGF-β) signaling is mainly transduced through the ALK5/smad2/3 pathway. Inhibition of TGF-β signaling would be predicted to enhance re-epthelialization of cutaneous wound and reduce scarring fibrosis. For determining an effective anti-TGF-β strategy for fibrosis, it is necessary to investigate the complex signaling of TGF-β. In this study, we synthesized a series of triazole analogues and evaluated their ALK5 inhibitory activity in p3TP-Lux assays. The compound 2 (p3TP-Lux, 21%), and 12a (p3TP-Lux, 6%) showed an inhibitory activity against ALK5. | - |
dc.description.tableofcontents | Ⅰ.Introduction 1 Ⅱ. Results and Discussion 9 Ⅲ. Conclusion 21 Ⅳ. Experimental Section 22 Ⅴ. References 49 Abstract in Korean 51 | - |
dc.format | application/pdf | - |
dc.format.extent | 904737 bytes | - |
dc.language | eng | - |
dc.publisher | 이화여자대학교 대학원 | - |
dc.title | Synthesis and Biological Evaluation of Novel 2-Pyridyl Substituted 1,2,3-Triazole Derivatives as Inhibitors of Transforming Growth Fractor-β TypeⅠReceptor | - |
dc.type | Master's Thesis | - |
dc.format.page | viii, 51 p. | - |
dc.identifier.thesisdegree | Master | - |
dc.identifier.major | 대학원 생명·약학부약학전공 | - |
dc.date.awarded | 2010. 8 | - |