View : 94 Download: 0
Aromatic Amino Carboxylic Acid의 Diazo化에 관한 연구
- Aromatic Amino Carboxylic Acid의 Diazo化에 관한 연구
- Issue Date
- 대학원 약학과
- 이화여자대학교 대학원
- It has been reported that diazotized amines decompose in the presence of certain reducing agents to form the common replacement derivatives with other products, including biaryls.
o-, m- and p- Chlorobenzoic acids were synthesized starting from o-, m- and p- aminobenzoic acids through the extended Sandmeyer reaction, respectively.
The experiment was intended to know the optimum concentration of cuprous chloride solution in hydrochloric acid according to various normalities ( 12N, 10N, 8N, 6N, 4N and 2N ) when the diazotized. amine was replaced with chloride radical.
The yIeld of chlorobenzoic acid considerably varied with the normality and volume of cuprous chloride solution.
In the case of o- and p- chlorobenzoic acid, their maximum yields were 71.9% and 90.6% at 6N HCl, respectively. Whils the maximum yield of m-chlorobenzoic acid was 77.2% at 4N HCl.
When the diazotized amine was also replaced with cyanide radical, p-cyanobenzoic acid synthesized with Sandmeyer reaction was yielded 44.3% and with tetracyanonickelate(ll)ion was yielded 41.3%.
- Show the fulltext
- Appears in Collections:
- 일반대학원 > 생명·약학부 > Theses_Master
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.