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Aromatic Amino Carboxylic Acid의 Diazo化에 관한 연구
- Aromatic Amino Carboxylic Acid의 Diazo化에 관한 연구
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- 대학원 약학과
- 이화여자대학교 대학원
- It has been reported that diazotized amines decompose in the presence of certain reducing agents to form the common replacement derivatives with other products, including biaryls.
o-, m- and p- Chlorobenzoic acids were synthesized starting from o-, m- and p- aminobenzoic acids through the extended Sandmeyer reaction, respectively.
The experiment was intended to know the optimum concentration of cuprous chloride solution in hydrochloric acid according to various normalities ( 12N, 10N, 8N, 6N, 4N and 2N ) when the diazotized. amine was replaced with chloride radical.
The yIeld of chlorobenzoic acid considerably varied with the normality and volume of cuprous chloride solution.
In the case of o- and p- chlorobenzoic acid, their maximum yields were 71.9% and 90.6% at 6N HCl, respectively. Whils the maximum yield of m-chlorobenzoic acid was 77.2% at 4N HCl.
When the diazotized amine was also replaced with cyanide radical, p-cyanobenzoic acid synthesized with Sandmeyer reaction was yielded 44.3% and with tetracyanonickelate(ll)ion was yielded 41.3%.
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