Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 연숙희 | - |
dc.creator | 연숙희 | - |
dc.date.accessioned | 2016-08-26T12:08:46Z | - |
dc.date.available | 2016-08-26T12:08:46Z | - |
dc.date.issued | 2001 | - |
dc.identifier.other | OAK-000000071748 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/189778 | - |
dc.identifier.uri | http://dcollection.ewha.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000071748 | - |
dc.description.abstract | 일반적으로 D-nucleosides의 거울상 이성질체인 L-nucleosides는 D-nucleosides보다 독성이 적은 것으로 알려져 있고, 항바이러스 활성과 항암 활성을 나타내면서 독성이 경감된 L-2'-deoxy-4'-thiopyrimidine nucleosides 유도체가 합성되었다. 또한 최근에 L-nucleosides와 4'-thionucleosides의 항암 활성과 항바이러스 활성도 보고되었다. 이러한 사실에 기인하여 새로운 L-1-(2-azido-2-deoxy-4-thioribo-furanosyl)cytosine을 합성하였다. 최종물질은 benzoic acid 2,4-bis-benzyloxy-1-(bis-benzylsulfanyl-methyl)-3-hydroxy-butyl ester을 출발물질로 하여 중요 중간체인 L-2-azido-2-deoxy-4-thioribofuranose를 거쳐 총 15 step으로 합성하였으며 전자 공여기와 전자 흡인기에 따라 핵산 염기의 축합 반응이 영향을 받는다는 것을 발견하였다.;Since L-nucleosides were in general found to be less toxic than their corresponding enantiomers, D-nucleosides, L-2'-deoxy-4'-thiopyrimidine nucleosides have been synthesized for the development of antiviral and anticancer agents. Several 2'-modified 2'-deoxy-4'-thiocytidines have been found to show potent antiviral and antitumor activities. Prompted by the impressive antiviral activity and toxicity profile displayed by L-nucleosides and 4'-thionucleosides, L-1-(2-azido-2-deoxy-4-thioribofuranosyl) cytosine was synthesized starting from D-xylose via the key intermediate, L-2-azido-2-deoxy-4-thioribofuranose as potential antiviral agent. | - |
dc.description.tableofcontents | List of Figures = ii Abstract = iii I. Introduction = 1 II. Results and Discussion = 7 III. Conclusion = 19 IV. Experimental Section = 20 References = 35 Abstract in Korean = 41 | - |
dc.format | application/pdf | - |
dc.format.extent | 750614 bytes | - |
dc.language | eng | - |
dc.publisher | 이화여자대학교 대학원 | - |
dc.title | Synthesis of L-1-(2-Azido-2-deoxyribofuranosyl)cytosine as potential antiviral agent | - |
dc.type | Master's Thesis | - |
dc.format.page | ii, 41 p. | - |
dc.identifier.thesisdegree | Master | - |
dc.identifier.major | 대학원 약학과 | - |
dc.date.awarded | 2001. 2 | - |