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油中乾燥法에 의한 Propranolol HCL Ethyl cellulose microencapsulation에 관한 연구 /

油中乾燥法에 의한 Propranolol HCL Ethyl cellulose microencapsulation에 관한 연구 /
Other Titles
Propranolol·HCl - Ethyl Cellulose Microencapsulation by Solvent Evaporation Method in Liquid Paraffin
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대학원 약학과
이화여자대학교 대학원
Acetone/Liquid paraffin system 유중건조법으로 지속성·서방성제형의 개발이 요구되는 β - adrenergic blocking agent인 Propranolol·HCL을 핵물질로 하고 Ethyl cellulose를 피막물질로 사용하여 microcapsule을 조제하였다. Propranolol·HCl 을 각각 19.74, 32.44, 47.67, 64.7, 81.7 및 88.04% 함유하고 약물량 손실이 적은 microcapsule을 조제할 수 있었다. 조제된 Propranolol.HCl-Ethyl cellulose(이하 PPH- EC)microcapsule을 주사전자현미경으로 관찰하여 본 결과 모두 구형이었다. PPH-EC microcapsule로 부터의 약물 용출속도는 propranolol HCl powder에 비해 상당히 지연되었다; Propranolol·HCl powder는 3분이내에 용출이 거의 완료되었으나 Propranolol·HCl을 각각 80 및 90% 함유하도록 설정한 PPH-EC microcapsule의 경우 각각 30분, 10분만에 용출이 완료되었고 설정약물량을 20, 33, 50 및 67%로 하여 조제한 PPH-EC microcapsule로 부터의 용출량은 4시간 동안 각각 18.98, 26.38, 87.53 및 100.01% 이었다. 또한 분산제로 사용한 sorbitan tristearate의 농도는 PPH-EC microcapsule로 부터의 약물 용출특성에는 거의 영향을 미치지 않았다.;Propranolol · HCl - Ethyl Cellulose (PPH-EC) Microcapsules were prepared by the solvent evaporation method in liquid paraffin/acetone system using sorbitan tristearate as a dispersing agent. The microcapsules containing 19.74, 32.44. 47.67, 64.70, 81.7 and 88.04% of propranolol · HCl were obtained without loss of drug in the process of preparation. Scanning Electron Microgram showed that the PPH-EC microcapsules were almost spherical. The dissolution rates of propranolol · HCl from the PPH-EC microcapsules retarded considerably compared with propranolol · HCl powder; dissolution of propranolol HCl powder was completed within 3 minutes, but dissolution of propranolol · HCl from PPH-EC microcapsules designed to contain 80 and 90% of propranolol · HCl were almost completed within 30 min and 10 min, respectively, and amounts of propranolol · HCl released from PPH-EC microcapsules designed to contain 20, 33, 50 and 67% of propranolol · HCl were 18.98, 26.38, 87.53 and 100.01% at 4 hr, respectively. And, the concentration of sorbitan tristearate did not affect the dissolution profiles of propranolol HCl from PPH-EC microcapsules.
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