Full metadata record
DC Field | Value | Language |
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dc.contributor.advisor | 서명은 | - |
dc.contributor.author | 신상희 | - |
dc.creator | 신상희 | - |
dc.date.accessioned | 2016-08-25T04:08:09Z | - |
dc.date.available | 2016-08-25T04:08:09Z | - |
dc.date.issued | 1991 | - |
dc.identifier.other | OAK-000000023271 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/180107 | - |
dc.identifier.uri | http://dcollection.ewha.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000023271 | - |
dc.description.abstract | Benz[f]indole-4,9-dione의 구조를 가지는 화합물들은 Gram-positive bacteria에 대하여 항박테리아 작용을 갖는다고 알려져 있으므로 분자내 고리화 반응을 이용하여 새로운 benz[f]indole-4,9-dione 유도체들을 합성하였다. 2-chloro-3-(α-cyano-α-ethoxycarbonyl-methyl)-1,4-naphthoquinone에 지방족 amine류를 ethanol에서 반응시켜 2-amino-3-ethoxycarbonyl-N-alkyl-benz[f]indole-4,9-dione 유도체 Ia-f를 합성하였다. 방향족 amine류와의 반응에서는 2-arylamino-3-(α-cyano-α-ethoxycarbonyl-methyl)-1,4-naphthoquinone 유도체 IIa-h만을 얻었을 뿐, 고리화 반응은 일어나지 않았으나, 방향족 amine류의 ethanol 혼합액에 triethylamine을 촉매로 첨가하면 분자내 고리화 반응이 진행되어 2-amino-3-ethoxycarbonyl-N-aryl-benz[f]indole-4,9-dione 유도체 IIIa-f를 얻을 수 있었다.;Compounds with benz[f] indole-4,g-dione moiety are known to have an antibacterial activity against Gram-positive bacteria. The new kinds of 2-amino-benz[f] indole-4,g-diones were prepared via intramolecular cyclization. 2-Chloro-3-(a-cyano-a-ethoxycarbonyl-methyl)-1,4-naphtho- quinone was reacted with some alkylamines to yield N-alkyl-2- amino-benz [f]indole-4,9-diones (compounds Ia-f). However, when it was treated with the arylamines, only 2-amino-3-( α-cyano-α- ethoxycarbonyl-methyl)-1,4-naphthoquinones (compounds IIa-h) were obtained without furthur cyclization. The ring-closed compounds, 2-amino-3-ethoxycarbonyl-N-aryl-benz[f] indole-4,9-diones (com- pounds IIIa-f), were prepared when triethylamine was employed as a base for the reaction of 2-ch1oro-3-(α-cyano-α-ethoxycar- bonyl-methly)-1,4-naphthoquionone and arylamines. | - |
dc.description.tableofcontents | CONTENTS ABSTRACT = ⅳ Ⅰ. INTRODUCTION = 1 Ⅱ. NOMENCLATURE = 9 Ⅲ. EXPERIMENTAL = 10 A. CHEMICALS and INSTRUMENTS = 10 B. PROCEDURES = 11 1. Preparation of 2-chloro-3-(a-cyano-a-ethoxycarbonyl-methy)-1,4-naphthoquinone(19) = 11 2. Preparation of 2-amino-3-ethoxycarbonyl-N-alkyl-benz-[f]indole-4,9-diones (Ia-f) = 11 3. Preparation of 2-N-arylamino-3-(a-cyano-a-ethoxy-carbonyl-methyl)-1,4-naphthoquinone(Ila-h) = 17 4. Preparation of 2-amino-3-ethoxycarbonyl-N-aryl-benz-[f]indole-4,9-diones(Illa-f) = 26 Ⅳ. RESULTS and DISCUSSION = 33 Ⅴ. CONCLUSION = 42 REFERENCES = 43 LIST of SPECRA = 45 논문초록 = 57 | - |
dc.format | application/pdf | - |
dc.format.extent | 2152347 bytes | - |
dc.language | eng | - |
dc.publisher | 이화여자대학교 대학원 | - |
dc.subject | Benz[f]indole-4 | - |
dc.subject | 9-dione | - |
dc.subject | Derivatives | - |
dc.subject | ntramolecular | - |
dc.subject | Cyclization | - |
dc.title | Synthesis of Benz[f]indole-4, 9-dione Derivatives via Intramolecular Cyclization | - |
dc.type | Master's Thesis | - |
dc.format.page | 56 p. | - |
dc.identifier.thesisdegree | Master | - |
dc.identifier.major | 대학원 약학과 | - |
dc.date.awarded | 1991. 8 | - |