3-메칠-2, 3-디히드로 벤즈 [f] 인돌-2, 4, 9-트리온 유도체의 합성

Abstract

3-Chloro-2-(1-methyl-1-diethoxycarbonyl) -methyl-1,4-naphthoquinone을 출발물질로하여 새로운 3-methyl-2,3-dihydrobenz[f]indole-2,4,9-trione유도체를 합성하였다. 즉 2,3-dichloro-1,4-naphthoquinone을 sodium amide존재하에서 α-methyl- diethylmalonate와 반응시켜 3-chloro-2-(1- methyl-1-diethoxycarbonyl)-methyl-1,4-naphthoquinone을 합성한 다음 이를 amino류와 반응시켜 3-methyl-2,3-dihydrobenz[f]indole-2,4,9-trione유도체를 합성하였다.;3-Methyl-2, 3-dihydrobenz[f] indole-2, 4, 9-trione derivatives were prepared from 3-chloro-2-(1-methyl-1-diethoxycarbonyl)-methyl-1, 4- naphthoquinone. When 2, 3-dichloro-1, 4-naphthoquione was reacted with α-methyl-diethylmalonate and sodium amide, 3-chloro-2-(1-methyl-1-diethoxycarbonyl)-methyl-1, 4-naphthoquinone was obtained. 3 - Chloro - 2 - (1 - methyl - 1 - diethoxycarbonyl) - methyl - 1, 4 -naphthoquione was reacted with various alkyl amines to give 3-methyl-3-ethoxycarbonyl-N-alkyl-2, 3-dihydrobenz[f] indole-2, 4, 9-triones in moderate 35% These new compounds are expected to have an antibacterial activity against gram-positive bacteria.