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N-포스포노 메틸 글리신의 새로운 합성법
- N-포스포노 메틸 글리신의 새로운 합성법
- Other Titles
- Novel Synthesis of N-Phosphonometh1 Glycine
- Issue Date
- 대학원 약학과
- N-포스포노 메틸 글리신; 합성법; N-Phosphonometh1 Glycine
- 이화여자대학교 대학원
- Benzylamine과 ethylchloroacetate를 DMSO solvent 에서 반응시켜 N-Benzylglycine을 합성하고 phosphorous acid, formaldehyde와의 Nannich-type 반응에 의하여 N-Benzyl-N- phosphonomethyl glycine을 합성하였다.
이 N-Benzyl-N-phosphonomethyl glycine을 가수소분해(Hydrogenolysis)하여 N-phosphonomethyl glycine을 합성하였다. 같은 방법으로 α, α'-Diamino-p-xylene으로부터 N-Phosphonomethyl glycine을 합성하였다.
가수소분해과정중 용매, 염기의 종류 및 양, pH에 따르는 반응속도의 변화를 연구하였다.;N-Benzyl-N-phosphonomethyl glycine was prepared from N-benzylglycine, which was obtained by the reaction of ethylchloroacetate and Benzylamine in DMSO solvent, phosphorous acid and formaldehyde by Mannich-type reaction.
Hydrogenolysis of N-benzyl-N-phosphonomythyl glycine with Pd-c catalyst gave N-phosphonomethyl glycine.
Also, N-phosphonomethylglycine was prepared from α, α'-diamino-p-xylene.
In the hydrogenolysis step, the effect of the solvent, pH, and base on the reaction time was examined.
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