Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 전은진 | - |
dc.creator | 전은진 | - |
dc.date.accessioned | 2016-08-25T02:08:51Z | - |
dc.date.available | 2016-08-25T02:08:51Z | - |
dc.date.issued | 2007 | - |
dc.identifier.other | OAK-000000018655 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/173135 | - |
dc.identifier.uri | http://dcollection.ewha.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000018655 | - |
dc.description.abstract | 1장에서는 Cu^(2+)와 Pb^(2+) 이온에 대해서 fluorescent chemosensor와 fluorescent chemodosimeter로 이용되는 BODIPY 유도체를 합성하였다. 센서 1은 여러 금속이온 중에서 Cu^(2+)와 Pb^(2+) 이온에 선택성을 보이고 큰 CHEF 효과를 나타내었다. 반면, fluorescent chemodosimeter인 센서 2는 acetyl group의 선택적인 가수분해 반응을 통해서 Cu^(2+) 이온을 효과적으로 인식하였다. 2장에서는 pH 7.4에서 nanomoral 범위의 Cu^(2+) 이온을 선택적으로 인식하는 fluorescein 유도체를 합성하였다. 이 형광 화학센서는 transferrin과 amyloid precursor protein에 의한 Cu^(2+) 이온 uptake를 관찰할 수 있었다. 3장에서는 pyrene group을 포함하는 binaphthyl 유도체를 합성하였고, 이것 또한 Cu^(2+) 이온에 대한 형광 화학센서로 연구되었다. Pyrene excimer emission의 형광 증가와 blue shift는 static pyrene excimer의 형성에 의해 관찰 될 수 있었다. 4장에서는 thiourea group을 포함하는 anthracene 유도체를 합성하고 그것의 결정 구조를 분석하였다. 이 형광 화학센서는 F- 이온에 대해서 ratiometric한 형광변화를 보였다.;Chapter I : New BODIPY derivatives (1 and 2) were synthesized as “off-on” fluorescent chemosensor and fluorescent chemodosimeter for Cu^(2+) and Pb^(2+). The compound 1 displayed selective and large CHEF (chelation enhanced fluorescence) effects with Pb^(2+) and Cu^(2+) among the metal ions examined. On the other hand, compound 2, a fluorescent chemodosimeter, effectively recognized Cu^(2+) via a selective hydrolysis of acetyl group. Chapter II : A new fluorescent chemosensor based on the fluorescein derivative effectively recognizes Cu^(2+) in nanomolar range at pH 7.4. The Cu^(2+) ion uptake by transferrin and amyloid precursor protein was monitored using the title fluorescent chemosensor. Chapter III : New binaphthyl derivatives bearing pyrene groups have been synthesized and studied as fluorescent chemosensors for Cu^(2+) ions. A unique blue shift along with fluorescent enhancement in pyrene excimer emission was observed, which were induced by the formation of a static pyrene excimer. Chapter IV : New anthracene derivatives bearing thiourea group have been synthesized and characterized including X-ray crystallography. These chemosensors display selective ratiometric changes in their fluorescence spectra upon the addition of fluoride ion. | - |
dc.description.tableofcontents | Abstract 1 Chapter I. New BODIPY Derivatives as OFF-ON Fluorescent Chemosensor and Fluorescent Chemodosimeter for Cu^(2+) : Cooperative Selectivity Enhancement toward Cu^(2+) 2 I-1. Introduction 3 I-2. Results and Discussion 4 I-3. Conclusion 15 I-4. Experimental Section 16 I-5. References 19 Chapter II. A fluoresein derivative for nanomolar aqueous copper and monitoring copper ion uptake by transferring and amyloid precursor protein 26 II-1. Introduction 27 II-2. Results and Discussion 28 II-3. Conclusion 39 II-4. Experimental Section 40 II-5. References 43 Chapter III. Unique blue shift due to the formation of static pyrene excimer : highly selective fluorescent chemosensor for Cu^(2+) 49 III-1. Introduction 50 III-2. Results and Discussion 51 III-3. Conclusion 58 III-4. Experimental Section 59 III-5. Reference 62 Chapter IV. Anthracene derivatives bearing thiourea group as fluoride selective fluorescent and colorimetric chemosensors 64 IV-1. Introduction 65 IV-2. Results and Discussion 66 IV-3. Conclusion 74 IV-4. Experimental Section 75 IV-5. Reference 78 국문초록 80 | - |
dc.format | application/pdf | - |
dc.format.extent | 3167713 bytes | - |
dc.language | eng | - |
dc.publisher | 이화여자대학교 대학원 | - |
dc.title | Fluorescent Chemosensors for Copper(II) and Fluoride Ion | - |
dc.type | Master's Thesis | - |
dc.format.page | ix, 82 p. | - |
dc.identifier.thesisdegree | Master | - |
dc.identifier.major | 대학원 나노과학부 | - |
dc.date.awarded | 2007. 2 | - |