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http://dspace.ewha.ac.kr/handle/2015.oak/171971
20200410T20:11:48Z

Detection of Fusion Genes Using a Targeted RNA Sequencing Panel in Gastrointestinal and Rare Cancers
http://dspace.ewha.ac.kr/handle/2015.oak/253533
Title: Detection of Fusion Genes Using a Targeted RNA Sequencing Panel in Gastrointestinal and Rare Cancers
Ewha Authors: 이수진
Abstract: Successful identification and targeting of oncogenic gene fusion is a major breakthrough in cancer treatment. Here, we investigate the therapeutic implications and feasibility of using a targeted RNA sequencing panel to identify fusion genes in gastrointestinal and rare cancers. From February through December 2017, patients with gastrointestinal, hepatobiliary, gynecologic, sarcoma, or rare cancers were recruited for a clinical sequencing project at Samsung Medical Center (NCT #02593578). The median age of the patients was 58 years (range, 3181 years), and the maletofemale ratio was 1.3 : 1. A total of 118 patients passed the quality control process for a nextgeneration sequencing (NGS) based targeted sequencing assay. The NGSbased targeted sequencing assay was performed to detect gene fusions in 3653 cancerimplicated genes. The following cancer types were included in this study: 28 colorectal cancers, 27 biliary tract cancers, 25 gastric cancers, 18 soft tissue sarcomas, 9 pancreatic cancers, 6 ovarian cancers, and 9 other rare cancers. Strong fusion was detected in 25 samples (21.2%). We found that 5.9% (7/118) of patients had known targetable fusion genes involving NTRK1 (n=3), FGFR (n=3), and RET (n=1), and 10.2% (12/118) of patients had potentially targetable fusion genes involving RAF1 (n=4), BRAF (n=2), ALK (n=2), ROS1 (n=1), EGFR (n=1), and CLDN18 (n=2). Thus, we successfully identified a substantial proportion of patients harboring fusion genes by RNA panel sequencing of gastrointestinal/rare cancers. Targetable and potentially targetable involved fusion genes were NTRK1, RET, FGFR3, FGFR2, BRAF, RAF1, ALK, ROS1, and CLDN18. Detection of fusion genes by RNA panel sequencing may be beneficial in refractory patients with gastrointestinal/rare cancers.
20200101T00:00:00Z

Ankle ultrasound for detecting anterior talofibular ligament tear using operative finding as reference standard: a systematic review and metaanalysis
http://dspace.ewha.ac.kr/handle/2015.oak/253509
Title: Ankle ultrasound for detecting anterior talofibular ligament tear using operative finding as reference standard: a systematic review and metaanalysis
Ewha Authors: 이선화
Abstract: Purpose To evaluate the diagnostic accuracy of ankle ultrasound for detection of anterior talofibular ligament (ATFL) tear with a reference standard of operative finding. Methods A computerized search of PubMed and EMBASE databases was performed to identify relevant original articles on ankle ultrasound for ATFL tear. The pooled proportions of the diagnostic accuracy estimates were assessed using randomeffects modeling. We also assessed pooled proportions of the diagnostic accuracy according to injury stage (acute or chronic) and severity of injury (complete or partial). Heterogeneity among studies was determined using the inconsistency index (I2). Metaregression analyses were performed to evaluate the potential sources of heterogeneity. Results Ten studies were included. The pooled proportion of the diagnostic accuracy of ankle ultrasound for ATFL was 0.95 (95% confidence interval [CI] 0.880.98). In subgroup analysis, the pooled proportion of the diagnostic accuracy of ankle ultrasound for acute ATFL tear was 0.92 (95% CI 0.850.95). The pooled proportion of the diagnostic accuracy of ankle ultrasound for chronic ATFL tear was 0.96 (95% CI 0.840.99). The pooled proportions of the diagnostic accuracy for complete and partial ATFL tear were 0.82 (95% CI 0.720.89) and 0.88 (95% CI 0.700.96), respectively. In the metaregression analyses, the inclusion of pediatric patients was only significantly different (p = 0.007). Conclusions Ankle ultrasound may be a useful diagnostic modality in the detection of ATFL tear in adults and children, regardless of injury stage and severity. For correct diagnosis of ATFL tear, a highfrequency ultrasound probe and sufficient experience of the examiner are mandatory.
20200101T00:00:00Z

Circuit presentation and lattice stick number with exactly four z sticks
http://dspace.ewha.ac.kr/handle/2015.oak/253474
Title: Circuit presentation and lattice stick number with exactly four z sticks
Ewha Authors: 김형준
Abstract: The lattice stick number sL(L) of a link L is defined to be the minimal number of straight line segments required to construct a stick presentation of L in the cubic lattice. Hong, No and Oh [Upper bound on lattice stick number of knots, Math. Proc. Cambridge Philos. Soc. 155 (2013) 173179] found a general upper bound sL(K) ≤ 3c(K) + 2. A rational link can be represented by a lattice presentation with exactly 4 zsticks. An ncircuit is the disjoint union of n arcs in the lattice plane 2. An ncircuit presentation is an embedding obtained from the ncircuit by connecting each n pair of vertices with one line segment above the circuit. By using a twocircuit presentation, we can easily find the lattice presentation with exactly four zsticks. In this paper, we show that an upper bound for the lattice stick number of rational p qlinks realized with exactly four zsticks is 2p + 6. Furthermore, it is 2p + 5 if L is a twocomponent link. © 2018 World Scientific Publishing Company.
20180101T00:00:00Z

Bipartite Intrinsically Knotted Graphs with 22 Edges
http://dspace.ewha.ac.kr/handle/2015.oak/253473
Title: Bipartite Intrinsically Knotted Graphs with 22 Edges
Ewha Authors: 김형준
Abstract: A graph is intrinsically knotted if every embedding contains a nontrivially knotted cycle. It is known that intrinsically knotted graphs have at least 21 edges and that the KS graphs, K7 and the 13 graphs obtained from K7 by del Y moves, are the only minor minimal intrinsically knotted graphs with 21 edges [1, 9, 11, 12]. This set includes exactly one bipartite graph, the Heawood graph. In this article we classify the intrinsically knotted bipartite graphs with at most 22 edges. Previously known examples of intrinsically knotted graphs of size 22 were those with KS graph minor and the 168 graphs in the K3,K3,K1,K1 and E9 + e families. Among these, the only bipartite example with no Heawood subgraph is Cousin 110 of the E9 + e family. We show that, in fact, this is a complete listing. That is, there are exactly two graphs of size at most 22 that are minor minimal bipartite intrinsically knotted: the Heawood graph and Cousin 110. (C) 2016 Wiley Periodicals, Inc.
20170101T00:00:00Z