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Yoon-Young Sung, Taesook Yoon, Seol Jang, Ho Kyoung Kim
Forsythia suspensa Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice
www.plosone.org
www.plosone.org
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(Korea\).)Tj
3.1974 0 Td
(A)Tj
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(voucher)Tj
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(specimen)Tj
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(KIOM-78039\))Tj
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[()3( )6()1(\n)4()]TJ
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1 J
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(animal)Tj
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(20)Tj
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(DfE)Tj
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(3)Tj
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(weeks.)Tj
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(11th)Tj
2.0013 0 Td
(day)Tj
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(the)Tj
1.474 0 Td
(first)Tj
1.8028 0 Td
(DfE)Tj
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(FSE)Tj
-34.6448 -1.2983 Td
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3.1577 0 Td
(every)Tj
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(day)Tj
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1.3889 0 Td
(23)Tj
1.1736 0 Td
(days.)Tj
2.2223 0 Td
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2.2224 0 Td
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(randomly)Tj
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(assigned)Tj
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1.8368 0 Td
(four)Tj
1.9162 0 Td
(groups)Tj
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(group\):)Tj
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(DfE-treated)Tj
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(control)Tj
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(mice)Tj
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(mg/mouse\),)Tj
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(treated)Tj
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(mice)Tj
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(that)Tj
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(applied)Tj
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(400)Tj
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1.6497 0 Td
[()]TJ
/F8 1 Tf
(g)Tj
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(of)Tj
1.0148 0 Td
(FSE,)Tj
2.0182 0 Td
(and)Tj
1.7292 0 Td
(DfE-treated)Tj
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(mice)Tj
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(that)Tj
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(applied)Tj
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(100)Tj
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[()]TJ
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(tacroli-)Tj
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(\(0.1%)Tj
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3.668 0 Td
(ointment,)Tj
4.1555 0 Td
(Astellas)Tj
3.2769 0 Td
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(Deerfield,)Tj
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(IL,)Tj
1.3209 0 Td
(USA\).)Tj
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(control.)Tj
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(topical)Tj
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(application,)Tj
4.9039 0 Td
(the)Tj
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(powder)Tj
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(dissolved)Tj
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(acetone:olive)Tj
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(oil)Tj
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([4:1)Tj
-35.892 -1.3039 Td
(\(v/v\)])Tj
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(DfE-treated)Tj
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(mice,)Tj
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(daily.)Tj
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(anesthesia)Tj
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(with)Tj
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(\(intraperito-)Tj
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(100)Tj
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(the)Tj
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(34th)Tj
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(day)Tj
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(the)Tj
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(collected)Tj
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3.8438 0 Td
[()3()2(\r)6( )]TJ
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[()7( )22()3( )]TJ
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(,)Tj
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1.7291 0 Td
(the)Tj
1.474 0 Td
(skin)Tj
1.8879 0 Td
(samples)Tj
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1.7291 0 Td
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-33.6016 -1.3039 Td
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Q
q
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1 J
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BT
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Q
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BT
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(assessed)Tj
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(macroscopically)Tj
6.6558 0 Td
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1.0261 0 Td
(the)Tj
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(following)Tj
-33.5449 -1.3039 Td
(four)Tj
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(symptoms:)Tj
4.5864 0 Td
(erythema/hemorrhage,)Tj
9.3996 0 Td
(edema,)Tj
3.0728 0 Td
(scarring/dryness,)Tj
7.0639 0 Td
(and)Tj
1.7291 0 Td
(excoriation/erosion,)Tj
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(and)Tj
-36.0394 -1.2982 Td
(the)Tj
1.4683 0 Td
(total)Tj
2.0012 0 Td
(clinical)Tj
3.0784 0 Td
(dermatitis)Tj
4.286 0 Td
(severity)Tj
3.2768 0 Td
(score)Tj
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1.3833 0 Td
(each)Tj
2.0296 0 Td
(mouse)Tj
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(defined)Tj
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1.9276 0 Td
(of)Tj
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Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 399.6283 745.7952 cm
BT
/F6 1 Tf
1 TL
-0.005 Tc
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(Forsythia)Tj
4.2661 0 Td
(Suspensa)Tj
/F0 1 Tf
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3.2386 0 Td
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0.978 0 Td
(the)Tj
1.5874 0 Td
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ET
Q
q
1 j
1 J
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36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
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BT
/F0 1 Tf
1 TL
-0.005 Tc
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(PLOS)Tj
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(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
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(687)Tj
2.6362 0 Td
(December)Tj
4.7622 0 Td
(9,)Tj
1.0418 0 Td
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